I hold PhD in Biochemistry, MS in Molecular Biology & Biotechnology and BS in Biology. I work as basic and translational research scientist in Cell Signaling Networks Laboratory at TJU (Philadelphia, PA, USA). The main focus of my research is Signal Transduction in normal and neoplastic cells and, more specifically, my interests include:
- Architecture, systems-level interactions and signaling dynamics of RTK signaling networks
- Context-dependent cross-talk of distinct intracellular signaling pathways and receptor networks
- Molecular mechanisms of intrinsic and acquired tumor chemoresistance
- Adaptor proteins as drug targets
- Signaling profiles of ischemic wound healing and liver regeneration
Quantitative comparative analysis of human growth factor, hormone and cytokine receptor signaling networks and their interactions in normal and cancer cells, benign and malignant tumors as well as between different types of metastatic adenocarcinomas may lead to discovery of subtle and more pronounced differences in signaling circuitry, fragility points amenable to therapeutic intervention and elucidation of the molecular mechanisms of cancer resistance to chemotherapy drugs, small molecule inhibitors and natural dietary compounds with anti-cancer potential. My long-term objective is to understand the mechanistic basis of cancer development and to translate the findings into new improved combinatory treatments for cancer patients. In addition, our knowledge is limited about the wound healing and regeneration processes in different therapeutic settings, and it is imperative to investigate the course of molecular events that would drive uncompromised wound repair in pathological conditions.
Goal of Website
Herewith, I would like to share my research experience & insights into Cell Signaling, which would fill a key NIH mandate for making published data and results available to the scientific community. Also, I feel an urge to acknowledge the work of my mentors and many other great scientists all over the World who have introduced me to the magical world of the Cell and inspired to explore the intricate molecular mechanisms controlling cell fate decisions and underlying various human diseases. Any questions and suggestions would be greatly appreciated! Together, we can make the World a better place.
I consider myself lucky, because I really love my job and feel genuine enthusiasm when performing both routine and novel challenging procedures. Being a scientist is self-rewarding profession. There is an element of surprise in every obtained experimental result, an element of patience, struggle and persistence when something does not work at once as expected, an element of poetry in writing the papers, an element of hope in writing the grants, an element of art in creating the figures and drawing the schemes, an element of quest in tracking the literature, using search engines and browsing the databases, an element of responsibility to meet the requirements and perform the tasks that fit into the project's time-frame, an element of freedom in designing the experiments, and element of Sherlock Holmes deduction when analyzing data, and last, but not the least, an element of humbleness when you approach the Cell and realize that there are so many things unknown and yet to be discovered...
I have a chance to constantly grow, gain and share knowledge. And it never gets boring, so one does not need to count hours until the end of the work day (I love working at nights when it is so calm! Sometimes I loose myself in the flow and may come back home after 2 days..) What amazes me is that the signaling mechanisms seem to be conservative, but in fact they are so diverse! The signal flow via intracellular pathways differs in cells from the same tissue origin even upon stimulation with the same type of the ligand, depending on the repertoire of expressed proteins... This is why there is no Universal Signaling Model for each given signaling network, just as there is no the Theory of Everything. Nevertheless, the tremendous efforts are put to analyze the growth factor, cytokine and hormone-mediated signaling networks in order to find the crucial differences between normal and malignant cells. And for a noble reason...
Metastasized pancreatic cancer took my grandmother's life away, whereas a stroke soon thereafter carried away my grandfather - them, whom I love and remain grateful the most, because they have raised me, educated, tought to love the nature and its inhabitants, encouraged me to study Biology, selflessly supported my decision to go abroad, patiently waited and joyfully greeted when I returned for vacations, being proud and excited about my acomplishments... The life-shaking loss just strengthened my motivation to further study and help conquer the Cancer. I remember and I create my music for them (even if our musical taste may be separated by generation gap and abyss of death).
Thank You for taking your time to visit my Website!